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PDUFA has more decreased evidence criteria by directing the company to utilize surrogate endpoints in the Accelerated Approval pathway. In basic principle, Accelerated Acceptance involves article-acceptance confirmatory reports employing clinically meaningful endpoints, but FDA enforcement of the need has actually been very poor. Most medicine obtaining accelerated approvals usually do not endure confirmatory research on time, should they bear them in any way, and damaging confirmatory trials don't always produce withdrawal.

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